This core course will cover the American Medical Informatics Association (AMIA) five domains of informatics: Translational Bioinformatics, Clinical Research Informatics, Applied Clinical Informatics, Consumer Health Informatics, Public or Population Health Informatics, and discuss respective career opportunities emerging in the public, non-profit, government, and independent sectors. The course provides practical knowledge of health, information science and technology, and social determinants of health to improve patient care through use of data technologies. The course also examines special topics including EHR systems, Pharmacy Management Systems, Revenue Cycle Management Systems, Health Information Exchange, Data Standards and Design, Health Equity, and Health IT Management. Additionally, the course will cover ethical, legal and regulatory issues as it relates to data privacy, managing personal health information (PHI), HIPAA compliance, Canadian Privacy Act, and European Parliament’s General Data Protection Regulation (GRPR). Finally, the course will include training on Python for healthcare, healthcare statistical data modeling, and research methodology.